Epigenetic Modifications of Host Genes Induced by Bacterial Infection

Epigenetic Modifications in Gram-Negative Bacteria and the Induction of Patho-Epigenetic Modifications in Host Tissue

The importance of epigenetic modifications in cancer progression

Epigenetics are dynamic and inherited changes in the genome that occur independently of DNA sequencing. This phenomenon requires coherent interaction with various enzymes and other molecular components. Abnormal epigenetic changes can lead to the onset of improper gene expression and the promotion of tumorigenesis. Because epigenetic changes are prone to external and reversible factors, they ar...

Host-induced modifications of viruses.

Viruses exhibit extensive adaptability to growth in various hosts or tissues. It was widely held in the past that virus adaptability reflected a peculiar plasticity of virus heredity, which allowed it to be directly influenced by its host cells. The alternative interpretation of virus adaptation to new host cells as due to spontaneous mutations, which provide a range of genotypes for the new ho...

Transcript analysis of some defense genes of tomato in response to host and non-host bacterial pathogens

The transcript levels of six defense genes including pathogenesis-related gene 1 (PR-1), pathogenesis-related gene 2 (PR-2), pathogenesis-related gene 5 (PR-5), lipoxygenase (LOX), phenylalanine ammonia-lyase (PAL) and catalase (CAT) were investigated in tomato plants inoculated with Xanthomonas axonopodis pv. phaseoli as a non-host pathogen and X. euvesicatoria as a host pathogen. Activation o...

Histone modifications induced by a family of bacterial toxins.

Upon infection, pathogens reprogram host gene expression. In eukaryotic cells, genetic reprogramming is induced by the concerted activation/repression of transcription factors and various histone modifications that control DNA accessibility in chromatin. We report here that the bacterial pathogen Listeria monocytogenes induces a dramatic dephosphorylation of histone H3 as well as a deacetylatio...

Importance of Gut Microbiota and Epigenetic Modifications in Maintaining Health or Diseases

 Some organisms may modulate a healthy state or cause disorders by disruption or induction of several signaling pathways in human body. According to recent evaluations, numerous metabolic disorders such as diabetes, obesity, cardiovascular diseases, mental disorders, and cancers are as the result of bacterial interactions with the host. Various species of the bacteria, called commensal microbio...